The roles and regulatory mechanisms of TGF-ß and BMP signaling in bone and cartilage development, homeostasis and disease.

Transforming growth factor-ßs (TGF-ßs) and bone morphometric proteins (BMPs) belong to the TGF-ß superfamily and perform essential functions during osteoblast and chondrocyte lineage commitment and differentiation, skeletal development, and homeostasis. TGF-ßs and BMPs transduce signals through SMAD-dependent and -independent pathways; specifically, they recruit different receptor heterotetramers and R-Smad complexes, resulting in unique biological readouts. BMPs promote osteogenesis, osteoclastogenesis, and chondrogenesis at all differentiation stages, while TGF-ßs play different roles in a stage-dependent manner. BMPs and TGF-ß have opposite functions in articular cartilage homeostasis. Moreover, TGF-ß has a specific role in maintaining the osteocyte network. The precise activation of BMP and TGF-ß signaling requires regulatory machinery at multiple levels, including latency control in the matrix, extracellular antagonists, ubiquitination and phosphorylation in the cytoplasm, nucleus-cytoplasm transportation, and transcriptional co-regulation in the nuclei. This review weaves the background information with the latest advances in the signaling facilitated by TGF-ßs and BMPs, and the advanced understanding of their diverse physiological functions and regulations. This review also summarizes the human diseases and mouse models associated with disordered TGF-ß and BMP signaling. A more precise understanding of the BMP and TGF-ß signaling could facilitate the development of bona fide clinical applications in treating bone and cartilage disorders.

How Social Exclusion Affects Consumers' Color Preference.

Social exclusion can cause negative changes on human beings both in the physiological and psychological aspects. Although considerable efforts have been devoted to study its effects on consumption behavior, little attention has been paid to the consequence that social exclusion might have on consumer's color preference and the underlying mechanisms. Such social events can change individual's behavior. This work examines the influence of social exclusion on consumers' color preference as well as the moderation and mediation effects via three experiments: Experiment 1 studies the impacts of social exclusion on consumer color choice (warm color versus cold color). To further validate the robustness of the results, experiment 2 is designed by replicating the findings of experiment 1 in another product category and instructed the participants to choose products with different colors. Meanwhile, the mediation effect of self-threat is examined. In Experiment 3, the moderation effect of self-construal is investigated via a 2 (exclusion vs. inclusion) × 2 (independent vs. interdependent) × (warm color vs. cold color) between-subjects design. Our results indicate that social exclusion makes people prefer warm colors rather than cold colors. However, these effects would be mediated by self-threat, which could be further moderated by self-construal. The present study establishes the relationship between social exclusion and consumers' color preference, which is expected to provide guidance for companies to improve product design and promotion strategies to adapt to various contexts.

Legitimacy, incipience, and perception of informal social control of intimate partner violence: Experiment on a Korean parent sample.

Evidence from a growing research literature on the causes and effects of informal social control (ISC) and bystander interventions carried out by nonprofessionals against intimate partner violence (IPV) shows anomalies and unexplained counterintuitive findings. This study employs a new experimental vignette design to examine the hypothesis: high bystander legitimacy (in the eyes of potential perpetrators) will moderate the effects of (1) incipient ISC and (2) perceived ISC, on parent's self-estimated likelihood of perpetrating IPV. The data consist of 210 rural Korean parents randomly drawn from Kyunggi province using a three-stage cluster probability proportional to size approach. Parents were randomly assigned to low and high incipient ISC, perceived ISC, and collective legitimacy conditions, following a 2 × 2 × 2 experimental vignette approach. Hypotheses were tested using regression models with standard errors corrected for district clusters. Incipient ISC was associated with significantly less self-estimated likelihood of perpetrating IPV. An interaction between high bystander legitimacy and incipient ISC was negative (B = -8.88, p < 0.01). The interaction between perceived ISC and legitimacy was not significant. However, the interaction between perceived ISC and female gender was positively associated with self-estimated likelihood of perpetrating IPV (B = 8.61, p < 0.05). The findings suggest that the presence of a legitimate bystander (whom the potential perpetrator believes has a legitimate right to be concerned about his or her family) may deter parents from perpetrating IPV. Programs to boost ISC and bystander intervention should include modules that strengthen collective legitimacy.

ALX1-transcribed LncRNA AC132217.4 promotes osteogenesis and bone healing via IGF-AKT signaling in mesenchymal stem cells.

The osteogenic potential of bone marrow mesenchymal stem cells (BMSCs) is critical for bone formation and regeneration. A high non-/delayed-union rate of fracture healing still occurs in specific populations, implying an urgent need to discover novel targets for promoting osteogenesis and bone regeneration. Long non-coding (lnc)RNAs are emerging regulators of multiple physiological processes, including osteogenesis. Based on differential expression analysis of RNA sequencing data, we found that lncRNA AC132217.4, a 3'UTR-overlapping lncRNA of insulin growth factor 2 (IGF2), was highly induced during osteogenic differentiation of BMSCs. Afterward, both gain-of-function and loss-of-function experiments proved that AC132217.4 promotes osteoblast development from BMSCs. As for its molecular mechanism, we found that AC132217.4 binds with IGF2 mRNA to regulate its expression and downstream AKT activation to control osteoblast maturation and function. Furthermore, we identified two splicing factors, splicing component 35 KDa (SC35) and heterogeneous nuclear ribonucleoprotein A1 (HNRNPA1), which regulate the biogenesis of AC132217.4 at the post-transcriptional level. We also identified a transcription factor, ALX1, which regulates AC132217.7 expression at the transcriptional level to promote osteogenesis. Importantly, in-vivo over-expression of AC132217.4 essentially promotes the bone healing process in a murine tibial drill-hole model. Our study demonstrates that lncRNA AC132217.4 is a novel anabolic regulator of BMSC osteogenesis and could be a plausible therapeutic target for improving bone regeneration.

A Comparative Study of Totalitarian Style Partner Control in Seoul and Beijing: Confucian Sex Role Norms, Secrecy, and Missing Data.

Totalitarian style partner control is seldom studied apart from intimate partner violence (IPV) independently as an outcome. This article uses a comparative study of Beijing and Seoul to begin to address this gap in the research. We collected three-stage probability proportional to size cluster samples of married/partnered women from Beijing (n = 301) and Seoul (n = 459), using refusal conversion to keep response rates high. We hypothesized (1) totalitarian style partner control will be positively associated with Confucian sex role norms at the (a) individual and (b) neighborhood levels, (2) totalitarian style partner control will be positively associated with IPV secrecy at the (a) individual and (b) neighborhood levels, and (3) totalitarian style partner control will be positively associated with the need for refusal conversion. Mixed effects (multilevel) regression models supported all three hypotheses at the individual level. Surprisingly, neighborhood socioeconomic status was positively associated with totalitarian style partner control. The combined data conceal important differences between Beijing and Seoul. The rate of totalitarian style partner control is more than 5 times higher in Seoul, and Confucian sex role norms, at both the individual and neighborhood levels, predict totalitarian style control there. Based on our findings, we infer that cultural emphases on face may play very different roles in the etiology of totalitarian partner control in the two cities.

TRPM7 Upregulate the Activity of SMAD1 through PLC Signaling Way to Promote Osteogenesis of hBMSCs.

TRPM7 is a member of the transient receptor potential cation channel (TRP channel) subfamily M and possesses both an ion channel domain and a functional serine/threonine α-kinase domain. It has been proven to play an essential role in the osteogenic differentiation of human bone marrow-derived mesenchymal stem cells (hBMSCs). However, the signaling pathway and molecular mechanism for TRPM7 in regulating osteogenic differentiation remain largely unknown. In this study, the potential role and mechanism of TRPM7 in the osteogenic differentiation of hBMSCs were investigated. The results showed that the expression of TRPM7 mRNA and protein increased, as did the osteogenic induction time. Upregulation or inhibition of TRPM7 could promote or inhibit the osteogenic differentiation of hBMSCs for 14 days. It was also found that the upregulation or inhibition of TRPM7 promoted or inhibited the activity of PLC and SMAD1, respectively, during osteogenic differentiation. PLC could promote osteogenic differentiation by upregulating the activity of SMAD1. However, inhibition of PLC alone could reduce the activity of SMAD1 but not inhibit completely the activation of SMAD1. Therefore, we inferred that it is an important signaling pathway for TRPM7 to upregulate the activity of SMAD1 through PLC and thereby promote the osteogenic differentiation of hBMSCs, but it is not a singular pathway. TRPM7 may also regulate the activation of SMAD1 through other ways, except for PLC, during osteogenic differentiation of hBMSCs.

A Tale of Two Confucian Capitals: The Role of Friends and Secrecy in Beijing and Seoul.

How do your friends respond to intimate partner violence (IPV), and does it make a difference? This article examines the relationships between wives' IPV secrecy, Confucian sex-role norms, informal social control by friends, totalitarian style partner control by husbands, and husbands' IPV in a study of Beijing and Seoul. Hypotheses were tested using a three-stage cluster sample of 760 married/partnered women from Beijing (n = 301) and Seoul (n = 459). Multilevel regression models run on the combined data found that totalitarian partner control by husbands was positively associated with husband IPV severity. Friends' protective approaches to informal social control of IPV were associated with less husband IPV severity, but punitive approaches were marginally associated with more. However, the combined findings gloss over very different findings for the two cities. The authors argue that the etiology of much IPV in Beijing is better characterized by social disorganization, but the etiology of much IPV in Seoul is better characterized by totalitarian control (deviant order).

Informal Control by Family and Risk Markers for Alcohol Abuse/Dependence in Seoul.

Although previous research documents a reliable relationship between physical intimate partner violence (IPV) victimization and alcoholism, relatively little research has examined new theoretical constructs in IPV research that may increase risk for or help buffer women from alcohol abuse/dependence. The purpose of the present study was to examine informal social control of IPV by family members as a protective factor against and coercive control as a risk factor for alcohol abuse/dependence in a small population sample of married women in Seoul, South Korea. We hypothesized that (a) informal social control by family members would be negatively associated with victim alcohol abuse/dependence and (b) husband's coercive control would be positively associated with victim alcohol abuse/dependence. We measured alcohol abuse/dependence (CAGE scale), IPV and coercive control by husbands, and informal social control of IPV (ISC_IPV) by extended family members in a three-stage random cluster sample of 462 married women in Seoul, South Korea. Both random effects regression and zero-inflated Poisson regression models found that ISC_IPV by extended family members was associated with a significantly lower CAGE scores, and coercive control was associated with significantly higher CAGE scores. Interventions to boost ISC_IPV by extended family members may mitigate some of the risk of alcohol abuse/dependence by victims.

Power and Control in Kathmandu: A Comparison of Attempted Power, Actual Power, and Achieved Power.

We argue that the concept of power has been inadvertently sidelined in recent theory and research on husband violence. Three types of relationship power may matter with respect to husband violence: attempted power, actual power, and achieved power. Analyses of a randomly selected representative sample of 270 married or partnered women in Kathmandu showed that actual power was related to husband violence prevalence, severity, and injury. Achieved power was related to husband violence prevalence and severity, and attempted power was related to husband violence injury. Implications are discussed.

Prenatal ultrasound diagnosis of 1 case of vesicoureteral reflux.

Vesicoureteral reflux (VUR) is defined as a retrograde flow of urine from the urinary bladder to the kidneys. VUR can lead to renal damage in presence of urinary tract infection. In this case report, we performed prenatal ultrasound diagnosis to identify VUR of a fetus. Furthermore, this VUR case was confirmed by postnatal micturating cystourethrogram (MCUG). Hence, prenatal ultrasound detection of VUR is considered to be useful because it may provide us evidence to design therapeutic strategy to prevent potential renal damage as early as possible.

Neighborhood informal social control and child maltreatment: A comparison of protective and punitive approaches.

This paper introduces a new measure of informal social control of child maltreatment (henceforth ISC_CM) by neighbors. Research literature typically uses collective efficacy (Sampson, Raudenbush, & Earls, 1997) to examine neighborhood informal social control. We argue that double standards about the application of informal social control to family versus street crime requires a measure of informal social control specific to child maltreatment. We also argue that how neighbors intervene may matter as much as whether they intervene. Neighbors may engage in ISC_CM aimed at protecting the child and calming the parent, or more punitive ISC_CM aimed at deterring future abuse. We tested the relationship of both with very severe physical abuse and with abuse related child behavior problems. We used a random, 2-stage cluster design of Hanoi to collect the sample. Thirty Hanoi wards were randomly selected using probability proportional to size sampling. A simple random sample of families in each ward was then drawn using local government lists of ward residents. Based on power analysis, the target sample size was 300. Of 315 residents contacted, 293 participated, yielding a response rate of 93%. Random effects regression models (which estimate a random effect for each ward) were run in Stata11. We found that protective ISC_CM is associated with lower odds of very severe physical abuse and lower reported externalizing problems when abuse is present. Perceived collective efficacy and punitive ISC_CM is not associated with lower odds of very severe physical abuse. Implications for research, policy and practice are discussed. We conclude that further investigation of neighbor ISC_CM is needed to replicate the findings in other cultural contexts, ultimately followed by experimental manipulation of ISC_CM in a neighborhood context to examine the effects on child maltreatment. If further research corroborates the current findings, the development of neighborhood intervention programs to enhance protective ISC_CM may assist materially in reducing very severe child abuse and negative consequences stemming from such abuse.

The Hutong effect: informal social control and community psychology in Beijing.

BACKGROUND: Nearly 2.4 million Beijing residents experience intimate partner violence (IPV) annually. Of these 2.4 million, over 800 000 are injured by IPV; more than 300 000 are injured badly enough to require medical attention. Informal social control exerted by neighbours in communities with high levels of family-community integration (like those made up of residents of traditional courtyard house-and-alley Beijing neighbourhoods called 'Hutongs') may protect against IPV injury compared with apartment dwellers. METHODS: We tested the protective effects of informal social control and Hutong residence in a randomly selected, three-stage cluster sample of Beijing families reporting IPV. Informal social control of IPV (ISC_IPV) was measured using two 7-question Likert scales developed by the first author. Interviewers were given detailed instructions on how to classify neighbourhoods as Hutong-style or not. We used a Sobel test to examine whether the Hutong effect was mediated by informal social control. The initial sample was of 506 families. Analyses were carried out on 113 families who reported any IPV in the last year. RESULTS: Random effects regression models showed that both acts of informal social control and Hutong residence were associated with less IPV injury. However, the protective finding for Hutong residence was not explained by informal social control, collective efficacy, characteristics of the IPV or demographic characteristics of respondents and households. CONCLUSIONS: The unique protective association with Hutong residence suggests that the benefits of community life remain insufficiently theorised and understood.

The peril of order? IPV, injury, and order in Mongolian families.

Despite its consistent and latent appearance in feminist accounts of intimate partner violence (IPV), the characterization of IPV as an elaborately ordered relationship whose norms are backed up by force is notably absent from the empirical IPV literature. Drawing on Emery's typology of IPV, we hypothesized a curvilinear relationship between order and IPV injury. We developed a measure of relationship order and implemented it in a representative, randomly selected cluster sample of 250 families from Ulaanbaatar, Mongolia. Controlling for the severity of the IPV, higher levels of order, but not lower levels, are associated with higher numbers of reported IPV injuries. Theoretical and practical implications of order as a risk factor are discussed.

How culture influences perspective taking: differences in correction, not integration.

Individuals from East Asian (Chinese) backgrounds have been shown to exhibit greater sensitivity to a speaker's perspective than Western (U.S.) participants when resolving referentially ambiguous expressions. We show that this cultural difference does not reflect better integration of social information during language processing, but rather is the result of differential correction: in the earliest moments of referential processing, Chinese participants showed equivalent egocentric interference to Westerners, but managed to suppress the interference earlier and more effectively. A time-series analysis of visual-world eye-tracking data found that the two cultural groups diverged extremely late in processing, between 600 and 1400 ms after the onset of egocentric interference. We suggest that the early moments of referential processing reflect the operation of a universal stratum of processing that provides rapid ambiguity resolution at the cost of accuracy and flexibility. Late components, in contrast, reflect the mapping of outputs from referential processes to decision-making and action planning systems, allowing for a flexibility in responding that is molded by culturally specific demands.

Desistance from intimate partner violence: the role of legal cynicism, collective efficacy, and social disorganization in Chicago neighborhoods.

This paper examined the relationship between reported Intimate Partner Violence (IPV) desistance and neighborhood concentrated disadvantage, ethnic heterogeneity, residential instability, collective efficacy and legal cynicism. Data from the Project on Human Development in Chicago Neighborhoods (PHDCN) Longitudinal survey were used to identify 599 cases of IPV in Wave 1 eligible for reported desistance in Wave 2. A Generalized Boosting Model was used to determine the best proximal predictors of IPV desistance from the longitudinal data. Controlling for these predictors, logistic regression of neighborhood characteristics from the PHDCN community survey was used to predict reported IPV desistance in Wave 2. The paper finds that participants living in neighborhoods high in legal cynicism have lower odds of reporting IPV desistance, controlling for other variables in the logistic regression model. Analyses did not find that IPV desistance was related to neighborhood concentrated disadvantage, ethnic heterogeneity, residential instability and collective efficacy.

The effect of culture on perspective taking.

People consider the mental states of other people to understand their actions. We evaluated whether such perspective taking is culture dependent. People in collectivistic cultures (e.g., China) are said to have interdependent selves, whereas people in individualistic cultures (e.g., the United States) are said to have independent selves. To evaluate the effect of culture, we asked Chinese and American pairs to play a communication game that required perspective taking. Eye-gaze measures demonstrated that the Chinese participants were more tuned into their partner's perspective than were the American participants. Moreover, Americans often completely failed to take the perspective of their partner, whereas Chinese almost never did. We conclude that cultural patterns of interdependence focus attention on the other, causing Chinese to be better perspective takers than Americans. Although members of both cultures are able to distinguish between their perspective and another person's perspective, cultural patterns afford Chinese the effective use of this ability to interpret other people's actions.

The effect of information overlap on communication effectiveness.

It makes sense that the more information people share, the better they communicate. To evaluate the effect of knowledge overlap on the effectiveness of communication, participants played a communication game where the "director" identified objects to the "addressee". Pairs either shared information about most objects' names (high overlap), or about the minority of objects' names (low overlap). We found that high-overlap directors tended to use more names than low overlap directors. High overlap directors also used more names with objects whose names only they knew, thereby confusing their addressees more often than low-overlap directors. We conclude that while sharing more knowledge can be beneficial to communication overall, it can cause communication to be locally ineffective. Sharing more information reduces communication effectiveness precisely when there is an opportunity to inform-when people communicate information only they themselves know.